Abstract:
Aims: This research aimed at determining the causal relationship between type 2 diabetes mellitus
(T2DM) and ovarian cancer using two-sample Mendelian randomization technique. This is because
there is an assumption that type 2 diabetes mellitus (T2DM) has a causal relationship with ovarian
cancer due to the alarming rising incidence statistics.
Study design: This study used a two-sample Mendelian Randomization (MR) design to undertake
the causal relationship investigation. Mendelian randomization technique uses genetic variants as
instrumental variables, which undergo random allocation at conception and are non-modifiable.
This makes it not to be affected by confounding factors and reverse causation. The MR techniques
employed are MR-Egger and Inverse Variance Weighted (IVW.)
Data sources: The outcome (ovarian cancer) summary statistics was retrieved from Ovarian
Cancer Association Consortium (OCAC), which has 66,450 samples (number of cases=25,509,
number of controls=40,941) of European population. The exposure (T2DM) summary genetic data
