Abstract:
Psoriasis is a common chronic inflammatory skin disease that is differentiated by
repeated occurrences of raised scaly and red skin plaques. It is generated through several
applications of drugs, strains, physical wounds to the skin and also for infectivity. Psoriasis is
identified by composite interactions of T-Cells, Dendritic Cells, Cytokines and downstream
transcription factors (type 1 Cytokines network). The effects of T-Cells in dermal layer
(CD4+ T-Cells) are well-studied in the disease dynamics of Psoriasis from mathematical as
well as biological context. But the concept of T-Cells in epidermal layer (CD8+ T-Cells)
for disease progression of Psoriasis has not yet been explored till now from mathematical
avenue. Here we introduce both CD4+ and CD8+ T-Cell, Dendritic Cell and Keratinocyte
population to notice the impact of them on immunopathogenic cell-biological mechanism of
Psoriasis. Numerical simulation is also furnished to establish the analytical outcomes.
Description:
Proceedings of 3rd Strathmore International Mathematics
Conference (SIMC 2015), 3 - 7 August 2015, Strathmore
University, Nairobi, Kenya.