Azole Resistant Aspergillus Fumigatus With Tr34/L98h Mutation From Clinical Isolates In, Kenya

Abstract

Objective: The aim of the study was to characterize aspergillus species from clinical samples. Design: Cross sectional study. Setting: The study was conducted at Kenya Medical Research Institute using archived aspergillus isolates. Subject: The study was performed on 54 archived clinical samples. Results: Nine Aspergillus fumigatus and two Aspergillus flavus were isolated out of which two A. fumigatus had TR34/L98H mutation. Conclusion: Although no information on prior azole exposure was available, the present study reports the first triazole resistant aspergillus in Kenya and calls for more surveillance and measures to contain the emergence of azole resistance in clinical practice.